Latham, it's time the stress-and-strain theory was relegated to the junk pile along with demoniac possession and blood letting.

LATHAM. You must have done something for your patients—

NIEMAND. A doctor must always do something for the patients who come to his office seeking help. First I gave them a thorough physical examination. I turned up some minor ailments—a slight heart murmur or a trace of albumin in the urine—but nothing of any significance. On the whole they were a remarkably healthy bunch of individuals, much more so than an average sample of the population. Then I made a searching inquiry into their personal life. Here again I drew a blank. They had no particular financial worries. Their sex life was generally satisfactory. There was no history of mental illness in the family. In fact, the only thing that seemed to be the matter with them was that there were times when they felt like hell.

LATHAM. I suppose you tried tranquilizers?

NIEMAND. Oh, yes. In a few cases in which I tried tranquilizing pills of the meprobamate type there was some slight improvement. I want to emphasize, however, that I do not believe in prescribing shotgun remedies for a patient. To my way of thinking it is a lazy slipshod way of carrying on the practice of medicine. The only thing for which I do give myself credit was that I asked my patients to keep a detailed record of their symptoms taking special care to note the time of exacerbation—increase in the severity of the symptoms—as accurately as possible.

LATHAM. And this gave you a clue?

NIEMAND. It was the beginning. In most instances patients reported the attack struck with almost the impact of a physical blow. The prodromal symptoms were usually slight ... a sudden feeling of uneasiness and guilt ... hot and cold flashes ... dizziness ... double vision. Then this ghastly sense of depression coupled with a blind insensate rage at life. One man said he felt as if the world were closing in on him. Another that he felt the people around him were plotting his destruction. One housewife made her husband lock her in her room for fear she would injure the children. I pored over these case histories for a long time getting absolutely nowhere. Then finally a pattern began to emerge.

LATHAM. What sort of pattern?

NIEMAND. The first thing that struck me was that the attacks all occurred during the daytime, between the hours of about seven in the morning and five in the evening. Then there were these coincidences—

LATHAM. Coincidences?

NIEMAND. Total strangers miles apart were stricken at almost the same moment. At first I thought nothing of it but as my records accumulated I became convinced it could not be attributed to chance. A mathematical analysis showed the number of coincidences followed a Poisson distribution very closely. I couldn't possibly see what daylight had to do with it. There is some evidence that mental patients are most disturbed around the time of full moon, but a search of medical literature failed to reveal any connection with the Sun.

LATHAM. What did you do?

NIEMAND. Naturally I said nothing of this to my patients. I did, however, take pains to impress upon them the necessity of keeping an exact record of the onset of an attack. The better records they kept the more conclusive was the evidence. Men and women were experiencing nearly simultaneous attacks of rage and depression all over southern California, which was as far as my practice extended. One day it occurred to me: if people a few miles apart could be stricken simultaneously, why not people hundreds or thousands of miles apart? It was this idea that prompted me to get in touch with an old colleague of mine I had known at UC medical school, Dr. Max Hillyard, who was in practice in Utica, New York.

LATHAM. With what result?

NIEMAND. I was afraid the result would be that my old roommate would think I had gone completely crazy. Imagine my surprise and gratification on receiving an answer by