title="[Pg 15]"/> vein is dissolved, is sometimes marked with great precision. In a case recorded by Dr. Davis,[19] a patient was convalescent from an attack of phlegmasia dolens, when death took place instantaneously, while the patient was in the act of changing the sitting for the recumbent posture; the left external iliac vein was thickened, and its internal tunic was studded in several places with deposits of adherent lymph. The portion most remarkable for this incrustation, as well as for other disease, was immediately beneath Poupart's ligament; the vein, although contracted, was manifestly pervious.

V. It has been shown in the previous sections, that secretions mixed with the blood will alter its properties, and influence the period of its coagulation: that when the blood is thus altered, it may pass through a vessel without leaving any trace of its passage; but that if it coagulates and remains in a vein, the coats of the vessel will then take on increased action. The exciting cause of the inflammation in such cases appears to be conveyed by means of the contents of the vessels to the vessels themselves. But, as in post-mortem examinations, the changes produced in the vessels are much more easily recognized than the alterations in their contents, the former have of late years almost exclusively occupied the attention of pathologists. The cases in which constitutional symptoms follow inflammation of the veins, will be found to divide themselves principally into three large classes. 1. Those in which one of the larger veins has been opened. 2. Those in which some portion of bone has been involved in the original lesion. 3. Those that occur after child-birth.

In each of these three classes of cases, a free communication will be found to exist between the injured part and the general circulation. The natural mode of sealing this communication, when it is no longer proper, is the coagulation of the blood in the veins of the injured part. When, from some constitutional affection, or from some local peculiarity of structure, this intention is not fulfilled, a ready passage remains open, through which the blood may become infected. When pus has been injected into the veins, it has frequently happened, that no great constitutional disturbance, and no signs of secondary inflammation, have been produced; but this is believed to have depended upon the coagula in the veins having prevented (as probably occurred in Experiments vii and viii) the foreign matter from finding its way along the vessels. But if this obstruction be not offered, or be overcome, then the appearance of secondary inflammation, accompanied by corresponding constitutional symptoms, will be produced.

If water be injected into the cancellous structure of bone, it will find its way out in drops through the apertures of the nutritious vessels. The ready communication which is thus shown to exist between the interior of bones and the veins, has been but too often exemplified by M. Cruveilhier's experiments of introducing mercury into their cancellous structure, and finding it subsequently in the vascular system. This fact assumes peculiar significance, when taken in conjunction with the very large proportion of cases, in which some portions of bone will be found to have been involved in the primary lesion, in those who have died of secondary inflammations. Of fifty-two consecutive cases, occurring in surgical hospital practice, of which I have preserved notes, in no less than forty-one was some portion of the osseous system implicated.

Again, in the third class of cases above-mentioned, if the vena cava be injected after parturition, the injection will very speedily find its way into the uterus.[20] The ready communication which is thus shown to exist between the vascular system and the local affection, in each of the three large classes of cases which usually give rise to subsequent disease, would of itself afford at least a very remarkable coincidence. But more direct evidence presents itself of the way in which the system becomes contaminated in these affections: thus, after an operation for hæmorrhoidal tumours, an effusion of lymph and pus has been found in the hæmorrhoidal veins,[21] from thence the same appearances have been traced to the inferior mesenteric vein, and the severity of the secondary affection, indicated both by the symptoms and the post-mortem appearances, has fallen upon the liver. These circumstances all tend to point to the venous system as the means by which morbid matter in such instances is introduced: and the still more conclusive facts afforded in the production of secondary disease, by injecting fluids into the veins,[22] allow scarcely a doubt to remain upon the mind, that the unprotected veins are the channels, in a very large proportion of cases, through which the blood becomes infected.

VI. The cancellous structure of bone may be compared to the cellular tissue in soft parts. When inflamed, its intervals become filled up by effusion from the vessels, and an abscess may be as accurately circumscribed in the hard as in the soft structures of the body. In a healthy constitution, the adhesive inflammation will, in this way, always precede the suppurative; but where the inflammation is not circumscribed by adhesion, the secretions may permeate from cell to cell in unadhering parts. In soft structures, a remedy is at hand for allowing the escape of the matter, by a free division of the parts; but in bone, where the same thing takes place, the hard unyielding sides offer an effectual obstruction to the escape of any effused fluid. The cells of the bone then may become infiltrated, and, unless the veins of the part have been closed, there is nothing to prevent the diseased secretions from finding their way into the circulation.

M. Cruveilhier assures us, that a single drop of mercury introduced into the cancellous structure of living bone, may subsequently be detected in the capillaries of the lung, where it becomes the centre of one or more patches of livid congestion. This experiment appears to afford a perfect illustration of the way in which diseased secretion may be conveyed into the circulation, when the natural processes of repair in bone are abortive. These processes are the same in bone as in the other structures of the body; viz., union by the first intention, and adhesive inflammation. In soft parts, as the fibrin, which forms the bond of union in the first of these, is absorbed, the divided veins collapse, and thus continue closed; but in bony structures, where the injured vessels are held open, as the fibrin which at first closed their extremities becomes removed, their channels may be left as much open to the diseased secretions of the part, as to the globule of mercury in M. Cruveilhier's experiment.

The low degree of organization in bone, and the comparative slowness with which actions are there carried on, render it, in a peculiar degree, liable to interruptions in the process of repair; especially when, as not unfrequently happens, there is reason to believe that the vitality of some portion of the