analysis.

The beam of neutrons is turned on for 35 to 40 seconds. It is then interrupted while platform and patient are rotated 180 degrees. The irradiation is resumed so that a uniform dose of neutrons bombards the patient from both front and back.

During the irradiation your patient receives a dose of radiation equivalent to approximately 10 ordinary chest X rays and one of the calcium isotopes in his bones (calcium-48) is activated to calcium-49. The latter has a half-life of only 8.8 minutes and so counting must begin soon after the irradiation.

A patient in position for whole body irradiation with neutrons generated by an accelerator. His arms and legs are surrounded by plexiglas containers filled with water and his head is encased in a plexiglas helmet. On either side of him are containers, which serve as standards, filled with an aqueous solution of a calcium salt. The patient is standing on a turntable that is rotated 180 degrees after half the irradiation is completed so that the dose of neutrons is uniformly distributed to the front and the back of the patient.

A patient in position for whole-body gamma-ray spectrometry. The detectors are scintillation crystals that produce pulses of light proportional in intensity to the energy of the gamma ray absorbed in the crystal. The patient is scanned from head to foot in approximately 12½ minutes at a rate that is varied to compensate for the gradual decay of the calcium-49 radioactivity during this period. Near the patient’s head are two calcium standard solutions in plexiglas containers.

The patient lies down in a padded aluminum box and, only 4 minutes after the irradiation is concluded, a ring of 4 gamma-ray scintillation detectors[10] begin to measure the gamma rays emitted by his body. These detectors, which are each 4 inches thick and 9⅜ inches in diameter, pass over his body from head to foot. This takes 12½ minutes and since the calcium-49 is decaying with a half-life of 8.8 minutes, the detectors are made to scan at a gradually decreasing rate to compensate for the reduced radioactivity during the later parts of the counting period. The figure on the next page shows the gamma-ray spectrum for the patient. Notice the peak corresponding to an energy of 3.1 MeV. Because there are small contributions to this energy peak from other activated products in the body, repeat counts are taken later (after the calcium-49 has decayed) so that these contributions can be measured and subtracted.

Twenty minutes after the irradiation period, the radioactivity of the calcium standards is measured by the same instrument. The ratio of the counts from your patient’s body to that of the standards is 0.210; this serves as an index of the calcium content of his body on this day. Because of the care taken to make the analysis repeatable, this index is probably accurate to about 1 or 2%.

Your patient’s disease usually results in a decrease of approximately 3% of the calcium in his body per year. Thus, by making the same measurement a year from now, you will be able to tell if your treatment is a success by noting that the calcium level in your patient’s bones has stopped decreasing at a dangerous rate.

In a Plastics Plant

The Problem

You are an analytical chemist working for a company that makes plastic. It is 11:30 a.m. and you have been called by the plant superintendent because some of the plastic coming from the plant has been showing a yellowish-brown discoloration. There seem to be only a few possible reasons for it, but no easy way to tell which one is correct. One possibility is that a copper tank, in which the plastic is prepared, is somehow being corroded by excess acid in the raw material and minute quantities of dissolved copper are discoloring the plastic. You could prove that this is the cause if you could find copper in the plastic, but the plant superintendent wants the answer immediately because a few hours delay in production will jeopardize a valuable contract, and ordinary chemical analysis would take several hours. How can you quickly determine if there is copper present in the plastic?